Funding brief: The CIPHER Grant Programme directly supports the development of early-stage investigators, awarding up to US$150,000 for up to two years to address research gaps in paediatric and adolescent HIV in resource-limited settings. This is a unique ‘stepping up’ opportunity, designed to give investigators the experience they need to compete for larger funding. The grants are resulting in personal and career development, capacity building on the ground, and research that informs critical management and care and leads to policy change.
Since 2013, CIPHER Grantees have been addressing key clinical and operational research gaps in paediatric and adolescent HIV. And they are doing this where it is needed the most, in low- and middle-income countries (LMICs); in fact, recognizing the importance of building research capacity, approximately 80% of funds are awarded to applicants from LMICs. The intention is to attract early-stage investigators – from inside and outside the field of HIV research – to address critical research questions, while providing a unique opportunity for professional development.
CIPHER has partnered with the World Health Organization to develop global research agendas on HIV testing, treatment and service delivery for paediatric and adolescent populations. CIPHER implements these global research priorities as a funder through its grant and fellowship programmes. The 2018/2019 round will focus on paediatric HIV operational science specifically.
The CIPHER Grant Programme is made possible with the generous support of Founding Sponsor ViiV Healthcare and Janssen. Its content is guided by experts in paediatric and adolescent HIV convened by the IAS.
The purpose of the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Grant Programme is to fund research projects with the potential to address critical research questions that remain unanswered in the global response in order to inform policy change and ensure better outcomes in infants and children living with and affected by HIV in resource-limited settings. Designed for early-stage investigators, a key aim of the programme is to build research capacity within resource-limited settings by fostering the next generation of investigators in paediatric HIV. It is intended to attract young investigators from inside and outside the field of HIV to paediatric. This will help encourage innovative ideas and lead to the design of evidence-based approaches and interventions to overcome major obstacles in the field.
The research funded by the CIPHER Grant Programme should focus on operational science in paediatric HIV and address the targeted research priorities outlined by the Research for an AIDS free generation: A global research agenda for paediatric HIV. Eligible research projects include original research that can contribute to broader scientific efforts by answering parts of larger questions within the identified research priorities, e.g., sub-studies or generation of important preliminary data that can help secure more substantial research funding for paediatric HIV research (see Annex I of the guideline).
The research funded by the CIPHER Grant Programme should focus on operational science in paediatric HIV and address crucial gaps in paediatric HIV research that impede optimal HIV diagnosis, treatment and care for infants and children affected by HIV in resource-limited settings. Eligible research projects include original research that falls within defined priority research questions. Meta-analyses and systematic reviews will also be considered if they make unique contributions to the outlined questions. PAEDIATRIC HIV (infants and children 0-10 years old, including the perinatal and in-utero period, studies on mother-baby pairs and HIV-exposed uninfected children)
● Optimal placement and timing of novel diagnostic tools for point-of-care use;
● Interventions to ensure timely linkage between HIV diagnosis, treatment and care;
● Interventions or strategies to improve access to and uptake of HIV testing services for infants and children, particularly community-based approaches;
● Factors that enable or hinder linkage to care and timely initiation of ART;
● Effective, feasible and acceptable testing strategies (including routine testing at birth) at entry points other than antenatal care for identifying undiagnosed HIV-positive infants and children in different epidemic settings.
● Safety, efficacy, acceptability, pharmacokinetics and optimal dosing of existing and new antiretroviral drugs and formulations, particularly with novel drug delivery systems;
● Strategies or interventions to improve adherence, and factors that impact their success;
● Optimal prevention and clinical management of co-infections, particularly tuberculosis;
● Impact of HIV infection and ART on short- and long-term outcomes, in particular noncommunicable disease;
● Short- and long-term virologic and immunologic outcomes of starting very early treatment in infants living with HIV (impact on functional cure).
● Strategies or interventions to improve access to, uptake of and retention in care, and factors that impact their success;
● Service delivery models to improve individual and programmatic outcomes along the HIV cascade, including integration of comprehensive HIV treatment and care into the maternal and child health platform;
● Psychosocial and family support strategies or interventions to improve individual and programmatic outcomes;
● Strategies or interventions to improve and support parents, caregivers and healthcare providers to facilitate HIV disclosure to children, as well as factors that impact their success; · Strategies or interventions to reduce stigma and discrimination experienced by children and their caregivers.
Donor Name: International AIDS Society (IAS)
Funding name: Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Grant Programme
● Letter of Intent deadline 26th, October, 2018, 18:00 CET
● Full Proposal deadline 25th, January, 2019, 18:00 CET
Funding details link: Click to view
Funding limit: The nature and scope of the proposed research will vary from application to application, and therefore, it is anticipated that the size and duration of each award will also vary. Awards will be funded for up to two years and for up to US$ 75,000 each per year (including direct research costs and applicable indirect costs). Second-year funding is contingent upon demonstration of satisfactory progress during year one. The CIPHER Grant Programme encourages collaborations between different study sites and institutions; at least 80% of the direct grant expenses have to be spent in LMICs.
Special Notes: Please contact with the donor directly for further clarification and understanding.
Project start date: Research starting date Between July and November 2019
Project duration: Up to two years
Eligible organization: As below
● Any individual with the skills, formal education and access to resources necessary to carry out the proposed research is welcome to submit an application to the CIPHER Grant Programme. The applicant must be the principal investigator (PI) of the proposed project. The PI should work with a mentor, his/her institutional colleagues and partners to develop the research plan. Eligibility criteria and mandatory supporting documents:
● The PI must be an early-stage investigator, i.e., an individual who obtained her/his terminal research degree (e.g., PhD, MD, MBBS or equivalent) less than 10 years before the application deadline.
● The PI must serve for the first time as primary PI. Primary PIs who have previously received a non-training research grant exceeding US$ 30,000 are not eligible.
● The PI must fulfil one of the following criteria prior to the submission deadline for the Letter of Intent:
o He/she is a clinical/research trainee (e.g., fellow, senior resident) at an academic institute or an institute whose primary mission is research.
o He/she has a faculty or comparable position (e.g., assistant professor, lecturer) at an academic institute or an institute whose primary mission is research.
o He/she has an established position at an organization with adequate research infrastructure to undertake the proposed research activities.
● The research project should demonstrate the potential to contribute to the optimization of HIV diagnosis, treatment and care for infants and children affected by HIV in resource limited settings by responding to identified research priorities (see Annex I).
● Applications are encouraged from any country, however please note that approximately 80% of available funds in any given year will be awarded to applicants from (meaning holding a passport from) low- and middle-income countries (LMICs) according to the World Bank classification.
● The PI must choose a mentor with relevant expertise in paediatric HIV research (mentor’s contact details and a letter of commitment will be requested from all applicants; a mentorship plan will be requested only from short listed applicants who are invited to submit a Full Proposal).
● The budget should reflect that at least 80% of the direct grant expenses will be spent in LMICs.
● A letter of support from the applicant’s institution is required, as well as a copy of the applicant’s terminal research degree diploma.
Eligible Country: Applications are encouraged from any country, however please note that approximately 80% of available funds in any given year will be awarded to applicants from (meaning holding a passport from) low- and middle-income countries (LMICs) according to the World Bank classification.
Submission mail: Not found
How to apply: Interested applicant may apply through the website (Click to view).
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