Coalition for Epidemic Preparedness Innovations (CEPI): Inviting applications for ‘Call for proposals for platform technologies to enable rapid vaccine development for epidemic prone infections’

Funding brief: The objective of this Call for Proposals is to identify and fund proposals for vaccine platform technologies that enable rapid vaccine development, fast scale up, and achieve clinical benefit quickly for reactive use in outbreaks of novel or previously unrecognized viruses. Proposals can include new platforms with the potential for rapidly making a vaccine using generally regarded as safe materials (GRAS); or those compressing the time of an existing (proven) platform to make it more responsive in an unknown threat situation.

To demonstrate the versatility of the platform the proposal should include studies on three pathogens from different families, including one from the WHO priority pathogens list and two well-characterized pathogens from Table 1 (see section 2.3 for more details). Proof-of-concept/efficacy should be demonstrated for all three pathogens in relevant animal models and two of the vaccine candidates in the proposal should be evaluated in Phase I clinical trials, with plans for in-depth analyses of immunological mechanisms of actions of the platform. (Note: Data generated prior to this call are acceptable in partial or complete fulfillment of the demonstration requirements for one or more model pathogen).

For reactive use in outbreaks, timing is essential and therefore we are requesting that the proposed projects aspire to meet the time goals below. Proposals should describe the current state of technology and the approach in the proposed project to get closer to fulfilling the following goals:
● Target a 16-week timeframe from identification of antigen to product release for clinical trials
● Target a 6-week timeframe from administration of first dose to achievement of clinical benefit (i.e. immune response likely to result in clinical benefit)
● Produce 100,000 vaccine doses within 8 weeks to impact an emerging outbreak (i.e. from Go decision to scale-up to production, fill, finish, and release)

Donor Name:  Coalition for Epidemic Preparedness Innovations (CEPI)
Funding name: Call for proposals for platform technologies to enable rapid vaccine development for epidemic prone infections

Deadline:
● 
Deadline for submission of step 1 proposals: at 4 p.m. CEST 17th, October, 2017
● February 2018 Deadline for submission of full proposals (Step 2)

Funding details link: http://cepi.net/cfp2

Funding limit: Not found

Special Notes: Please contact with the donor directly for further clarification and understanding.

Project start date: Not found
Project duration: Not found

Eligible organization: As below

Eligibility: This call for proposals is open worldwide to vaccine relevant R&D entities that bring the relevant expertise and experience to address challenges within the scope of this call. Funding beneficiaries must be legal entities, or consortia of at least two legal entities. Applicant organizations or consortia of partnering organizations should have experience in vaccine development, i.e. a track record of bringing vaccine candidates through to human clinical trials in the last ten years. CEPI may conduct due diligence reviews for feasibility verification, legal, business and financial compliance before awards are made.

This call is open for proposals on vaccine platform technologies that can provide data from a vaccine candidate on the proposed platform that demonstrate immunogenicity using a relevant animal model. These data could be based on studies with the pathogens targeted in this call, or on another pathogen, ideally an outbreak-prone virus.

Eligible Country: No country bar found (Open to all regions)

Submission mail: N/A

Other important link:
● 
Apply: https://www.forskningsradet.no/en/Funding/CEPI/1254023147196
● Guideline: http://cepi.net/sites/default/files/CEPI_CfP2_guidelines%20for%20online%20application.pdf
● Format: http://cepi.net/sites/default/files/CEPI_CfP2%20step%201_Project%20description%20template.docx
● Milestone: http://cepi.net/sites/default/files/CEPI_CfP2%20step%201_Milestone%20template.xlsx
● Budget: http://cepi.net/sites/default/files/CEPI_CfP2%20step%201_Budget%20template.xlsx
● FAQ: http://cepi.net/sites/default/files/FAQs%20%20to%20be%20published.pdf

How to apply:
● Interested applicant may apply through the website (https://www.forskningsradet.no/en/Funding/CEPI/1254023147196 ).
● A milestone plan (for each target pathogen), showing the key activities and events on a relevant timescale (which should also be sent to cfp@cepi.net in excel format)
● A completed budget plan (which should also be sent to cfp@cepi.net in excel format)

 

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